Trial Spotlight

BRUIN CLL-322; NCT04965493

A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab Versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma*

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Enrolling

Breast

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
CDK4/6 Inhibitor
3
Not enrolling
CDK4/6 Inhibitor
3
Not enrolling
CDK4/6 Inhibitor
3
Not enrolling
CDK4/6 Inhibitor
3
Not enrolling
FRα Antibody-Drug Conjugate
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 1
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 2
1
Enrolling
Selective Estrogen Receptor Degrader
1
Not enrolling
Selective Estrogen Receptor Degrader
3
Not enrolling
Selective Estrogen Receptor Degrader
3
Enrolling

Gastrointestinal

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
FRα Antibody-Drug Conjugate
1
Enrolling
KRAS G12C Inhibitor
2
Enrolling
KRAS G12D Inhibitor
PRECLINICAL
Nectin-4 Antibody-Drug Conjugate 1
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 2
1
Enrolling

Genitourinary

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
FGFR3 Inhibitor
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 1
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 2
1
Enrolling
Prostate-Specific Membrane Antigen (PSMA)
1
Enrolling

Gynecologic

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
FRα Antibody-Drug Conjugate
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 1
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 2
1
Enrolling
Selective Estrogen Receptor Degrader
1
Not enrolling

Hematologic

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
BTK Inhibitor
2
Not enrolling
BTK Inhibitor
3
Not enrolling
BTK Inhibitor
3
Not enrolling
BTK Inhibitor
3
Enrolling
BTK Inhibitor
3
Not enrolling
BTK Inhibitor
3
Not enrolling

Lung

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
FRα Antibody-Drug Conjugate
1
Enrolling
KRAS G12C Inhibitor
2
Enrolling
KRAS G12C Inhibitor
3
Enrolling
KRAS G12D Inhibitor
PRECLINICAL
Nectin-4 Antibody-Drug Conjugate 1
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 2
1
Enrolling
RET Inhibitor
3
Not enrolling
RET Inhibitor
3
Enrolling
SMARCA2 (BRM) Inhibitor
1
Not enrolling
VEGF Receptor-2 Antagonist
3
Not enrolling

Other Solid Tumors

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
CDK4/6 Inhibitor
2
Not enrolling
FGFR3 Inhibitor
1
Enrolling
KRAS G12C Inhibitor
2
Enrolling
KRAS G12D Inhibitor
PRECLINICAL
Nectin-4 Antibody-Drug Conjugate 1
1
Enrolling
Nectin-4 Antibody-Drug Conjugate 2
1
Enrolling
RET Inhibitor
2
Enrolling
RET Inhibitor
2
Enrolling
SMARCA2 (BRM) Inhibitor
1
Not enrolling

Sarcoma

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
CDK4/6 Inhibitor
2
Enrolling
VEGF Receptor-2 Antagonist
2
Not enrolling

Thyroid

Therapeutic Target
Molecule
Trial Identifier
Phase
Status
RET Inhibitor
2
Enrolling
RET Inhibitor
3
Not enrolling