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Myostatin Antibody


Tags: supportive care, phase II

Myostatin Antibody Derived from Joulia-Ekaza D and Cabello G.1


Myostatin is a highly specific regulator of skeletal muscle belonging to the TGFβ superfamily of secreted growth factors. Inhibiting myostatin function may lead to increases in skeletal muscle mass and strength.2,3


LY2495655 is a humanized antibody designed to bind to myostatin and neutralize its function.4

Clinical Development

LY2495655 is being investigated in a clinical trial in patients with cancer-associated muscle wasting.

[NCT01505530]    Supportive Care    A Phase 2 Study of LY2495655 in Participants With Pancreatic Cancer