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Myostatin Antibody

LY2495655

Tags: supportive care, phase II

Myostatin Antibody Derived from Joulia-Ekaza D and Cabello G.1

Target

Myostatin is a highly specific regulator of skeletal muscle belonging to the TGFβ superfamily of secreted growth factors. Inhibiting myostatin function may lead to increases in skeletal muscle mass and strength.2,3

Molecule

LY2495655 is a humanized antibody designed to bind to myostatin and neutralize its function.4

Clinical Development

LY2495655 is being investigated in a clinical trial in patients with cancer-associated muscle wasting.

[NCT01505530]    Supportive Care    A Phase 2 Study of LY2495655 in Participants With Pancreatic Cancer