Derived from Joulia-Ekaza D and Cabello G.1
Myostatin is a highly specific regulator of skeletal muscle belonging to the TGFβ superfamily of secreted growth factors. Inhibiting myostatin function may lead to increases in skeletal muscle mass and strength.2,3
LY2495655 is a humanized antibody designed to bind to myostatin and neutralize its function.4
LY2495655 is being investigated in a clinical trial in patients with cancer-associated muscle wasting.